Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Modeling of Mixing-Sensitive Pharmaceutical Drug Substance Processes in Batch Reactors

F. Akpinar [1], B. Cohen [1], J. Tabora [1], A. Glace [1], K. Lauser [1], F. Lora Gonzalez [1], J. Albrecht [1],
[1] Bristol-Myers Squibb, New Brunswick, NJ, USA

Manufacturing of pharmaceutical drug substances involves chemical unit operations that are dependent on effective mixing, particularly reactions and crystallizations. Poor mixing can cause uneven distribution of chemical species in stirred tanks, leading to impurity formation and decrease in selectivity during reactions, and localized supersaturation, uncontrolled nucleation, impurity entrapment ...

CFD Simulation of Internal Flow Field of Dual-mode Scramjet - new

C. Butcher[1], K. Yu[1]
[1]University of Maryland, College Park, MD, USA

The complex internal flow field of a hypersonic air-breathing propulsion engine was modeled using COMSOL Multiphysics® software. This type of flow field can be found in a dual-mode scramjet engine. After creating the geometry, a 2D CFD simulation was run using the High Mach Number Flow physics interface in the CFD Module. A stationary time study was run and the results from the CFD simulation ...

Numerical Modeling and Performance Optimization Study of a Dehumidification Process in Nuclear Waste Storage

P. Geraldini[1]
[1]Sogin Spa, Rome, Italy

One of the main parameters to consider during the nuclear waste storage design phase is the drum corrosion risk. The humid-air corrosion models available in literature predict that, for carbon steel, the phenomena start to become appreciable for relative humidity (RH) values close to 65%. In general, the corrosion rate increases exponentially with relative humidity above the RH threshold. To ...

Multiscale Model of Human Pathogen Growth on Fresh Produce - new

A. Warning[1], A. K. Datta[1]
[1]Department of Biological & Environmental Engineering, Cornell University, Ithaca, NY, USA

Predictive food microbiology currently first requires experimental data for growth on fresh produce and then fitting an empirical or semi-empirical model to the data, making extrapolation to other conditions (temperature, type of produce) difficult. Herein, we develop a mechanistic model for the growth of human pathogenic bacteria (Escherichia coli O157:H7 and Salmonella spp.) on spinach using ...

Simulation of Gravity-Driven Flow Through a Microfluidic Device on a Rocker Platform - new

B. Srinivasan[1], J. Hickman[1], M. Shuler[2]
[1]University of Central Florida, Orlando, FL, USA
[2]Cornell University, Ithaca, NY, USA

A micropump delivers fluid between different components of a microfluidic device in a controlled manner. The elimination of micropump can reduce the design complexity, simplify fabrication, shrink the device footprint and decrease the set-up time required for the operation of the microfluidic device. One such pumpless microfluidic device for body-on-a-chip application for drug toxicity studies ...

Numerical Study of Smoldering Combustion of Activated Carbon in Ⅱ Iodine Absorber - new

T. Liang[1], M. Liu[1], X. Liu[1], Z. Meng[1]
[1]Safety Engineering, Zheng Zhou University, Zheng Zhou, Henan, China

Iodine absorber is a widely used purification equipment for purifying air in a nuclear power plant. In China, the common type is Ⅱ iodine absorber. Impregnated activated carbon is the main absorber within the iodine absorber. Because of the decays exothermic of radioactive iodine, heat is generated in the adsorption process. Carbon is a combustible material. Moreover, air is always supplied in ...

Virtual Functional Product Development of a µ-Methane Steam Reformer

T. J. Kazdal [1], M. J. Hampe [1],
[1] Technische Universität Darmstadt, Darmstadt, Germany

A micro steam methane reformer is a complex product consisting of multiple units. For the virtual functional product development it is necessary to validate these sub models separately. Therefore a reactor was designed to analyse kinetics of chemical reactions. The reactor design is based on a simulation geometry and the boundary conditions of the simulation were recreated in the experimental ...

Simulation of Molecular Transport of an Electroporated Cell using COMSOL Multiphysics®

J. V. D. Jayasooriya [1], D. Nawarathna [1],
[1] Department of Electrical and Computer Engineering, North Dakota State University, Fargo, ND, USA

Electroporation is a highly efficient cellular transfection method which is used to inject molecules into living cells. The electroporation involves creating temporary pores in cell membranes using an electrical field. It has been successfully utilized in medicine and biology for producing knockout mice, gene therapy, and cell-based therapy. As electroporation is an easy and rapid method, it is ...

Modeling an Enzyme Based Electrochemical Blood Glucose Sensor with COMSOL Multiphysics

S. Mackintosh[1], J. Rodgers[1], S.P. Blythe[1]
[1]Lifescan Scotland, Inverness, Scotland

This paper describes the modeling of a blood glucose sensor using COMSOL Multiphysics. Chemical species interaction and diffusion, coupled with electrochemical oxidation of multiple blood species produced a powerful working model used in developing and refining a range of blood glucose sensors for the commercial market.

Mathematical Model of Vacuum Foam Drying - new

M. Sramek[1], J. Weiss[2], R. Kohlus[1]
[1]Department of Food Processing Engineering, Institute of Food Science and Biotechnology, Hohenheim University, Stuttgart, Germany
[2]Department of Meat Science and Food Physics, Institute of Food Science and Biotechnology, Hohenheim University, Stuttgart, Germany

The mathematical model is closely related to the development of a novel drying method for high viscous and sticky materials. The foamed state facilitates diffusive moisture transport and therefore accelerating the drying process. Moreover the dried porous material can be easily converted into the powder. The mathematical modelling aimed at evaluating the complex drying process as basic ...