R. Penjweini, M. M. Kim, T. C. Zhu
Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA, USA
Introduction: Singlet oxygen (¹O₂) has a critical role in the cell-killing mechanism of photodynamic therapy (PDT). Therefore, in this study, the distance-dependent reacted ¹O₂ is numerically calculated using finite-element method (FEM). Herein, we use a model [Ref. 1] that has been previously developed to incorporate the diffusion equation for the light transport in tissue and the macroscopic ...
R. Sikorski, T. Merrill
Rowan University, Glassboro, NJ, USA
Stroke is caused by an interruption of brain blood supply and is one of the leading causes of death and disability. A mild reduction of 2-5°C in tissue temperature through hypothermia has shown reduced tissue infarct size, increased tissue recovery, and positive neurological effects. This paper seeks to predict the outlet blood temperature in the common carotid bifurcation branches. In our ...
A. González-Suárez, M. Trujillo, J. Koruth, A. D'Avila, E. Berjano
Biomedical Synergy, Electronic Engineering Department,Universitat Politècnica de Valencia, Valencia, Spain
Instituto Universitario de Matemática Pura y Aplicada, Universitat Politècnica de Valencia, Valencia, Spain
Helmsley Cardiac Electrophysiology Center, Mt SinaiMedicalCenter and School of Medicine, New York, NY, USA
Previous studies proposed using bipolar radiofrequency ablation across two catheters placed on opposing surfaces of the ventricular wall to create transmural lesions. 2D and 3D models were built and solved with COMSOL Multiphysics software. With these models, it was possible to study the temperature distribution and lesion geometry (Figure), to compare the potential of two ways of applying ...
G. Zhang, Y. Zhao, J. Brcka, J. Faguet, E. Lee
Clemson University, Clemson, SC, USA
TEL U.S. Holdings, Inc., U.S. Technology Development Center, Austin, TX, USA
In our experiments with manipulating cells with DEP, we noted that some cells are constantly spining. By hypothesing that the cell spining is caused by the non-circular shape of the cell body and the off-centered location of its nucleus and that the rotation direction depends on the relative location of nucleus with respect to the electrical field, we found that the observed cell rotation was ...
J. C. Kumaradas, A. Zhang, Y. D. Davletshin
Ryerson University, Toronto, ON, Canada
University of Waterloo, Waterloo, ON, Canada
Tremendous progress is being made in the integration of nanoparticles into micro-analytical systems for biosensing. These materials are shown to enhance the analyte capture capability of biosensing platforms. We have implemented a computational model that considers the sensor’s geometry, size, analyte concentration and type to predict the number of nucleic acid molecules captured by ...
李娜 , 李江红 
研究头部损伤机理是对运动撞击中脑损伤进行预测的有效手段。数学模型是分析损伤实验数据、预测人员碰撞损伤程度的唯一方法，但现有的头部损伤有限元模型基于尸体实验数据，且忽略脑组织结构的各向异性。本项目旨在提出并实现一种以损伤生物力学为基础、结合磁共振扫描 DTI 的轴突走向信息的有限元力学模型。提取脑外伤前的弥散张量成像信息，实现深入到轴突水平有限元力学模型的建立，在有限元模拟中采用非线性超弹性力学模型，并植入 NSGAII 最优化方法对有限元模型的材料参数进行优化，从而提高模型的稳定性和计算精度；将计算预测结果与损伤后 DTI 的 FA 值所表现的轴突断裂情况进行验证， 探索活体环境下碰撞损伤中脑轴突的损伤性变化，从而获得脑外伤损伤程度与力学因素之间的关系，为脑外伤损伤程度的预测和脑外伤损伤标准的校正提供精确完整的信息。本项目的研究成果将在汽车碰撞的乘员防护设计上有重要的理论指导价值。 ...
P. Wijdenes , H. Ali , N. Syed , C. Dalton ,
 Centre for Bioengineering Research and Education, University of Calgary, Calgary, AB, Canada
 Department of Electrical and Computer Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB, Canada
 Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada
Our inability to record single cell activity with high resolution over a long period of time precludes fundamental understanding of nervous system functions, both under normal and pathological conditions. While the fabrication of current micro- and nano-electrodes has advanced our capabilities to perform long-term recordings, this has been at the expense of signal resolution due to low sealing ...
Laser Interstitial Thermo Therapy (LITT) for Prostate Cancer Animal Model: Numerical Simulation of Temperature and Damage Distribution
M.F. Marqa, P. Colin, P. Nevoux, S. Mordon, and N. Betrouni
University of Lille, CHRU, Lille, France
Laser interstitial thermotherapy (LITT) is a cancer treatment technique in which laser fibers are introduced inside the tumor. While it destroys deep tumors, the LITT procedure allows minimizing the impact on adjacent healthy structures. One of the effective methods to perform treatment planning for LITT is simulation. We used COMSOL Multiphysics to simulate the heat distribution and thermal ...
A. Jeremic, E. Khosrowshahli
McMaster University, Hamilton, ON, Canada
Although mammography is extremely important diagnostic technique, it suffers from some limitations such as false negative and positive results, using ionizing radiation and patient’s discomfort. Microwave imaging has been recently proposed as an additional medical imaging technique which can potentially overcome some of the shortcomings of the mammography. We believe that the accuracy of ...
F. Mavelli , E. Altamura , P. Stano ,
 University “Aldo Moro”, Chemistry Department, Bari, Italy
 Science Department, Roma Tre University, Rome, Italy
Giant vesicles (GVs) are artificial chemical systems largely used as cell models, since they are micrometer-sized closed compartments bounded by a semi-permeable membrane, which in turn is composed by self-assembling amphiphiles. By opportunely engineering the lipid membrane and by entrapping cascade-reaction enzymes inside GVs, it is possible to design micro-sized reactors where metabolic ...