Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Modeling Interface Response in Cellular Adhesion

G. Megali[1], D. Pellicanò[1], M. Cacciola[1], F. Calarco[1], D. De Carlo[1], F. Laganà[1], and F.C. Morabito[1]

[1]DIMET Department, Faculty of Engineering, University “Mediterranea” of Reggio Calabria, Reggio Calabria, Italy

Constitutive properties of living cells are able to withstand physiological environment as well as mechanical stimuli occurring within and outside the body. We examined fluid flow and Neo-Hookean deformation related to the rolling effect. A mechanical model to describe the cellular adhesion with detachment is here proposed. We developed a finite element analysis, simulating blood cells attached ...

Simulation of Chemotractant Gradients in Microfluidic Channels to Study Cell Migration Mechanism in Silico

P. Wallin[1], E. Bernson[1], J. Gold[1]
[1]Chalmers University of Technology, Applied Physics, Biological Physics, Gothenburg, Sweden

Cell migration of endothelial cells along gradients is an important process in vivo and an interesting target for cancer therapeutics. Microfluidics offer very powerful tools to study such migration processes in detail in the lab. In this study, we describe a model to simulate molecular gradients in a diffusion based microfluidic gradient generator and how a cell senses these gradients via cell ...

A Study on Nutrient Mass Transport through Porous Channeled Flat Sheet Membrane and Prediction of Maximum Scaffold Thickness for Viable Cell Culture (In-vitro) by 3D Modeling for Tissue Engineering Application

N. M. S. Bettahalli[1], B. J. Papenburg [2], D. S. Stamatialis [2], M. Wessling [3]
[1]University of Twente, Enschede, The Netherlands & BMS College of Engineering, Bangalore, India
[2]University of Twente, Enschede, The Netherlands
[3]RWTH Aachen University

Tissue engineering (TE) is a multidisciplinary field involving principles of engineering and life sciences to improve the health and quality of life by repairing, restoring, maintaining, or enhancing tissue and organ function using cells, scaffolds, and growth factors alone or in combination. There are several artificial tissues that are already being used which include fabricated skin, ...

Numerical Prediction of Particle Dynamics Within a Cytometer. Application to Counting and Sizing by Impendance Measurement

D. Isèbe[1]
[1]HORIBA Medical, Montpellier, France

This paper describes how to numerically tackle the problem of counting and sizing particles by impedance measurement in an orifice–electrode system. The model simulate the particle dynamics submitted to strong hydrodynamic stresses through a microorifice and compute the voltage pulses generated by the modification of the inner dielectric medium. This FSI problem is solved on a moving mesh by ...

Computational design and analysis of Microwave Tomography in Intracerebral Hemorrhage

Priyadarshini Natarajan [1], Rajkumar ElagiriRamalingam[1]
[1]Division of Biomedical Engineering, School of Biosciences and Technology, VIT University, Tamil Nadu, India

Intracerebral hemorrhage is a condition where a blood vessel in the brain ruptures and causes internal bleeding leading to hemorrhagic stroke. 800 in every 100,000 people suffer from stroke each year and it's one of the major causes of mortality worldwide. Diagnosis involves Neurological examination with MRI/CT scans which is costly and time consuming. Microwave Tomography (MWT) is proposed as a ...

A Multiscale-Multiphysics Model for Axon Pathfinding Simulation, the Example of the Olfactory System

G. Naldi[1], G. Aletti[1], P. Causin[1]
[1]Dipartimento di Matematica ‘F. Enriques’, Università degli Studi di Milano, Milano, Italy

In the developing embryo, neurons form connections by projecting axons to appropriate target areas. The projection process includes neurite elongation, resulting from the assembly of new cytoskeletal material at the free end of the axon, a complex cascade of steering decisions, driven by biomechanical properties of the surrounding environment and by signals in it. In this work we focus on the ...

A Multiphase Porous Medium Transport Model with Distributed Sublimation Front to Simulate Vacuum Freeze Drying

A. Warning[1], J. M. R. Arquiza[1], A. K. Datta[1]
[1]Cornell University, Ithaca, NY, USA

A continuum, porous medium formulation with non-equilibrium sublimation was developed and validated for freeze drying without and with uniform microwave volumetric heating. The model incorporates the effect of Knudsen flow at low pressure and low permeability freeze drying. The distributed, non-equilibrium sublimation demonstrated that the sublimation front is a sharp boundary for high ice ...

基于 DTI 纤维追踪和有限元力学模型的脑损伤轴突纤维损伤研究

李娜 [1], 李江红 [2]
[1] 中南大学湘雅三医院,长沙,湖南,中国
[2] 中车集团南车研究所,株洲,湖南,中国

研究头部损伤机理是对运动撞击中脑损伤进行预测的有效手段。数学模型是分析损伤实验数据、预测人员碰撞损伤程度的唯一方法,但现有的头部损伤有限元模型基于尸体实验数据,且忽略脑组织结构的各向异性。本项目旨在提出并实现一种以损伤生物力学为基础、结合磁共振扫描 DTI 的轴突走向信息的有限元力学模型。提取脑外伤前的弥散张量成像信息,实现深入到轴突水平有限元力学模型的建立,在有限元模拟中采用非线性超弹性力学模型,并植入 NSGAII 最优化方法对有限元模型的材料参数进行优化,从而提高模型的稳定性和计算精度;将计算预测结果与损伤后 DTI 的 FA 值所表现的轴突断裂情况进行验证, 探索活体环境下碰撞损伤中脑轴突的损伤性变化,从而获得脑外伤损伤程度与力学因素之间的关系,为脑外伤损伤程度的预测和脑外伤损伤标准的校正提供精确完整的信息。本项目的研究成果将在汽车碰撞的乘员防护设计上有重要的理论指导价值。 ...

Kinetics of Proteins in the Blood-Brain Barrier

K. Gandhi [1],
[1] University of California, Riverside, CA, USA

The delivery of chemotherapy for cancer into the central nervous system, in particular the brain, remains a challenge. This results in brain metastases commonly being a cause of death from cancer. Here, we look at the environment of the blood-brain barrier. Then, we explore two proteins (breast cancer resistance protein and p-glycoprotein) that may inhibit the transport of medications (erlotinib ...

Virtual Thermal Ablation in the Head and Neck using COMSOL Multiphysics

U. Topaloglu[1], Y. Yan[2], P. Novak[2], P. Spring[3], J. Suen[3], and G. Shafirstein[3]
[1] Department of Information Technology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[2]Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
[3]Department of Otolaryngology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA

Thermal ablation in the head and neck requires accurate thermal dose delivery to target tissue while protecting the structure and function of nearby tissue and organs. In this study, we present a method that allows importing Computed Tomography (CT) scans to COMSOL, in order to model accurately the expected pathological outcomes prior to thermal ablation treatment. Thermal ablation of a virtual ...