E. Bianchi, M.F. Bello, I. Critelli, G. Dubini
Politecnico di Milano, LaBS, Laboratory of Biological Structure Mechanics, Milano, Italy
Swiss Federal Institute of Technology (EPFL), Laboratory of Life Sciences Electronics - Swiss Up Chair, Lausanne, Switzerland
A microfluidic thermal cycler for Polymerase Chain Reaction (PCR) has been modeled. A microliter sample is driven along the microchannel by a flow generated by means of electroosmotic micropumps, activated in sequence. Several multichannel pumps configurations have been separately modeled and the efficiency of each device has been evaluated with regard to the effective flowrate and the back ...
X. Xu, T. Patel, R.W. Hoyt
U.S. Army Institute of Environmental Medicine, Natick, MA, USA
A human torso model was created for heat transfer analysis. The torso was derived from the ‘Virtual Family’ whole-body voxel data from the ITIS Foundation (Zurich, Switzerland). Measurements were taken from the ITIS male along the axial plane at key anatomical landmarks and used to develop geometry in Solidworks. Individual components were created to represent the skin, fat, muscle, and bone ...
K. A. Bodnyk, G. J. Noble, N. Fitzpatrick, M. J. Allen, K. Stephenoff, R. T. Hart
Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA
Fitzpatrick Referrals, Godalming, Surrey, United Kingdom
Department of Veterinary Medicine, The Ohio State University, Columbus, OH, USA
The elbow joint in dogs constitutes a complex interaction of three bones, the humerus, radius and ulna. Medial coronoid disease (MCD) is a common cause of lameness in dogs, i.e. fracturing of the most prominent portion of the ulnar joint surface driven in flexion and in pivot against both the humerus and the radius. The cause remains unknown, but prior studies suggest joint incongruency as an ...
L. Garber[1,2], G. S. B. Williams, W. J. Lederer
Fischell Department of Bioengineering, University of Maryland, Baltimore, MD, USA
Center for Biomedical Engineering & Technology, University of Maryland, Baltimore, MD, USA
This project involves a simplified biological problem that was used to test the potential of COMSOL Multiphysics® software for cardiac myocyte spatial modeling. We made several assumptions to simplify the biological complexity and to highlight the geometrical structures (i.e., lack of sarcoplasmic reticulum, lack of contractile apparatus). We explored the role of the t-tubular network on ...
Department of Mathematics, Monmouth University, West Long Branch, NJ, USA
Atherosclerotic lesions preferentially develop in certain regions like bifurcations, branches, and bends [1, 2]. A possible explanation for such a preferential localization of atherosclerosis is that the geometry of the vessel influences the blood flow pattern. It suggests that the arterial geometry plays an important role in determining the localized blood flow information. Thus hemodynamic ...
J. Wala, D. Maji, S. Dhara, S. Das
Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India
Cells are complex entities which not only passively sense external stimuli (viz. chemical, optical or mechanical) but also interact with extracellular matrix (ECM) by regulating cellular behavior such as growth, proliferation, migration, etc. Monitoring cell growth and migration of adherent cells becomes a crucial factor in determining cell-cell and cell-substrate interaction, important for ...
A. Gizzi, C. Cherubini, S. Migliori, and S. Filippi
Nonlinear Physics and Mathematical Modeling Lab, Engineering Faculty, University Campus Bio-Medico, Roma, Italy
International Center for Relativistic Astrophysics, University of Rome La Sapienza, Roma, Italy
Alberto Sordi Foundation, Research Institute on Aging, Roma, Italy
Postoperative or paralytic Ileus (PI) is a temporary aftermath of major abdominal surgeries. PI prevents the passage of food throughout the lumen leading to bloating, distension, emesis and pain. A plausible mathematical model for this phenomenology physiologically fine tuned including thermal variations, is presented here. Using COMSOL Multiphysics the existing intestinal ionic model have been ...
Image-based Simulation of Electrical Impedance Techniques Applied on the Human Thorax for Cardio-pulmonary Applications
A. Harkara, R.M. Heethaar, R.T. Cotton, and F.K. Hermans
Simpleware Ltd., Exeter, UK
VU University Medical Center, Amsterdam, Netherlands
For medical diagnostic purposes there is an increasing need for non-(or minimal) invasive techniques to measure all kinds of parameters that can provide insight in the functioning of cells, organs or organ systems. Currently, Impedance Cardiography (ICG) is used for measurements of the heart and Electric Impedance Tomography (EIT) is used for investigating lung tissue condition. The PDE is ...
D. Iber, D. Menshykau, and P. Germann
Department of Biosystems Science and Engineering
Organogenesis is a tightly regulated process that has been studied experimentally for decades. Computational models can help to integrate available knowledge and to better understand the underlying regulatory logic. We are currently studying mechanistic models for the development of limbs, lungs, kidneys, and bone. We have tested a number of alternative methods to solve our spatio-temporal ...
Simulation of a Magnetic Induction Method for Determining Passive Electrical Property Changes of Human Trunk Due to Vital Activities
H. Mahdavi, J. Rosell Ferrer
Universitat Politècnica de Catalunya, Barcelona, Spain
The human body consists of many different types of tissues each with specific passive electrical properties. Vital activities lead to a characteristic change of these properties and geometrical changes. Magnetic induction is a non-contact method which can be used to determine these changes. The method is based on the creation of a primary magnetic field that will produce eddy currents in the ...