Here you will find presentations given at COMSOL Conferences around the globe. The presentations explore the innovative research and products designed by your peers using COMSOL Multiphysics. Research topics span a wide array of industries and application areas, including the electrical, mechanical, fluid, and chemical disciplines. Use the Quick Search to find presentations pertaining to your application area.

Dried Reagent Resuspension for Point of Care Testing (Analysis at the Patient Bedside)

M. Huet [1],
[1] Department of Biotechnology, CEA/Université Grenoble-Alpes, Grenoble, France

A microfluidic component was designed to collect blood from a finger prick by capillary flow and to perform biological analysis. It was used to perform ABO blood typing experiments in one step, the blood drop deposit, by agglutination of red blood cells (RBC) using embedded dried reagents. The present study is a first step in the modeling of the whole agglutination assay. Blood typing ...

Electrical Stimulation of Brain using a realistic 3D Human Head Model: Improvement of Spatial Focality

A. Datta, M. Elwassif, and M. Bikson

Department of Biomedical Engineering, The City College of the CUNY, New York, NY, USA

We calculated the spatial distribution of the electric fields induced in the brain during transcranial current stimulation (TCS). The spatial focality obtained using ‘concentric-ring’ configurations is investigated using a realistic MRI derived 3D finite element model of the human head. Two disc electrode configurations were simulated using COMSOL Multiphysics. The distant-bipolar ...

Drug Distribution in the Human Eye

L. Murtomäki[1], T. Kainuvaara[1]
[1]University of Helsinki, Helsinki, Finland

Drug therapy of the posterior segment of an eye is very challenging due to the difficult accessibility. Modern drugs often are large molecules, such as peptides, antibodies or oligonucleotides which are administrated, e.g. by intravitreous injections which requires clinical conditions. Computer modeling can be helpful in designing new and less invasive routes of drug administration. COMSOL is ...

Simulation of Normal and Cancerous T-cell Membrane Electroporation - new

O. Henao[1], V. Gómez[1], I. De la Pava[1], J. Sánchez[1]
[1]Grupo Fisiología Celular y Aplicada, Universidad Tecnológica de Pereira, Pereira, Risaralda, Colombia

Electroporation is an increase of the cell membrane permeability due to the formation of aqueous pores in it when the cell is under the influence of an intense electric field [1][2]. The formation of such pores in the membrane can be used to enhance the uptake of chemotherapeutic drugs into the cell in a cancer treatment known as electrochemotherapy [3]. In some cases the direct experimental ...

3D-FEA of the Relationship between the Occiput and Sphenoid in the Osteopathic Paradigm - new

Y. Chiesa[1]
[1]Istituto Superiore di Osteopatia, Milan, Italy

The concept of cranial Primary Respiratory Mechanism (MRP) is used by osteopathic practitioners to explain the perceptual characteristics arising from the clinical palpation approach of the human skull. The theoretical apparatus and the same MRP existence is always element of controversy among the scientific community. The results arising from this study highlight the intrinsic capability of ...

An Efficient Finite Element Analysis on an RF Structure Used to Evaluate the Effect of Microwave Radiation on Uveal Melanoma Cells

A. Dulipovici[1], D. Roman[2], I. Stiharu[2], and V. Nerguizian[1]

[1]École de technologie supérieure, Montreal, Quebec, Canada
[2]Concordia University, Montreal, Quebec, Canada

The use of Microwave/RF energy on cancer cells is explored for tumor ablation using medium power level ranging between a few Watts to about 50 Watts. In this research, low power levels, less than 100 mWatt, are used to evaluate the effect of this energy on Uveal melanoma cells by proliferation tests. The COMSOL simulation of the RF structure used to evaluate the radiation energy on ...

Effect of a High Frequency Field on the Electric Double Layer Surrounding a Biomolecule in a Fluid - new

M. Riou[1], C. Maedler[1], S. Erramilli[1], P. Mohanty[1]
[1]Boston University, Boston, MA, USA

Biosensors based on silicon nanowires are of great interest for ultrasensitive biomolecular recognition of disease specific markers for early stage diagnosis [1]. However, there are limitations on the performance of these nanosensors in solutions at high ionic strength. This is because the electric field induced by the binding of biomolecule is partially screened on length-scales larger than the ...

Computational Design and Optimization of Bone Tissue Engineering Scaffold Topology

N. P. Uth [1], J. Mueller [2], B. Smucker [3], A. Yousefi [1],
[1] Department of Chemical, Paper, and Biomedical Engineering, Miami University, Oxford, OH, USA
[2] Research Computing Support, Miami University, Oxford, OH, USA
[3] Department of Statistics, Miami University, Oxford, OH, USA

Introduction: Bone tissue has a limited ability for regeneration; critically sized defects cannot self-heal and require medical intervention. Bone tissue engineering (TE) circumvents this issue by growing replacement bone tissue from the patient’s own cells inside scaffolds. TE scaffolds are porous constructs that act as a support structure during bone regeneration and helps cells attach and ...

Passive and Active Deformation Processes of 3D Fibre-Reinforced Caricatures of Cardiovascular Tissues

A. Di Carlo[1], P. Nardinocchi[2], T. Svaton[3], and L. Teresi[1]

[1]Modelling and Simulation Lab, Università Roma Tre, Roma, Italy
[2]Dept. of Structural & Geotechnical Engineering, Università di Roma La Sapienza, Roma, Italy
[3]Dept. of Mathematics, University of West Bohemia, Pilsen, Czech Republic

In this paper, we present a mathematical model of contractile elastic solids meant to simulate various districts of the cardiovascular system, and based on the concepts of active deformation and embedded muscle fibres. Specifically, here we deal with the modeling of the gross mechanics of the Left Ventricle (LV) which is strictly related to its pump function. As is well known, the effectiveness ...

Solid Food Pasteurization by means of Ohmic Heating: Influence of Process Parameters

M. Zell[1], D. Cronin[1], D. Morgan[1], F. Marra[2], and J. Lyng[1]
[1]School of Agriculture, Food Science and Veterinary Medicine, Agriculture and Food Science Centre, College of Life Sciences, UCD Dublin, Ireland
[2]Dipartimento di Ingegneria Chimica e Alimentare, Università degli Studi di Salerno, Italy

Pasteurization of solid food undergoing ohmic heating has been analyzed using COMSOL Multiphysics on the basis of a previously validated multiphysics model. The simulation of pasteurization by ohmic heating involves simultaneous solution electrical potential within the food, heat transfer, and the kinetics transport of death of microorganisms. In the model, thermo-physical and electrical ...