Theoretical and Practical Approach for Transdermal Drug Delivery using Microneedle for Successful Skin Penetration

Jeevan J.Mahakud[1], Ziaur Reheman[2]
[1]Department of electronics and Communication engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
[2]Department of electronics and instrumentation engineering, Institute of technical education and research, Bhubaneswar, Odisha, India
Published in 2013

With the advent of MEMS, transdermal drug delivery has been developed to increase skin permeability for drug transport. Various microneedle structures have been analyzed theoretically as well as through simulation using COMSOL Multiphysics®. Then computational fluid dynamics has been presented in order to study the behavior of the fluid flow inside the microneedle cavity. In this report, the microneedle array interaction while insertion to human skin or soft tissues has been analyzed and simulations has been carried out to verify the structure deformation and fluid interaction with the surface. For controlled drug delivery, optimized structures of hollow microneedles can be fabricated thereby, increasing the permeability of the skin as well as transdermal transport of fluid molecules or drug.