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More services...Chemical Reactions in a Microfluidic T-Sensor: Numerical Comparison of 2D and 3D Models
R. Winz1 2 , N. Schröder1 , W. Wiechert1 , and E. von Lieres1
1 Institute of Biotechnology 2, Research Centre Jülich, Jülich, Germany
2 Research Center for Micro and Nanochemistry, University of Siegen, Siegen, Germany
In recent years lab-on-microchip technology has become a powerful tool for micro-scale analysis of biochemical processes. In the studied system the overall process consists of transport, convection, diffusion, reaction and adsorption processes. Two compounds A and B, contained in a carrier fluid (buffer), are introduced into a reaction channel via a Y-shaped double-inlet. As the streams flow laminary side by side, inter-diffusion allows for mixing of the two compounds. While mixing, these two compounds react to form a third complex C. It is only the latter compound that is then adsorbed at a functionalized surface, coated with receptors to form a complex bond (donor-acceptor-bond). The amount of adsorbed molecules C’ can be quantified via an increase in fluorescence.
